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KMID : 0605620170240040225
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Journal of Korean Society of Biological Psychiatry
2017 Volume.24 No. 4 p.225 ~ p.234
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Alterations of Cortical Folding Patterns in Patients with Bipolar I Disorder : Analysis of Local Gyrification Index
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Lee Jun-Yong
Han Kyu-Man
Won Eun-Soo
Lee Min-Soo
Ham Byung-Joo
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Abstract
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Objectives : Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. Several studies have suggested altered local gyrification in patients with bipolar I disorder (BD-I). The purpose of the present study was to investigate the alterations in the cortical gyrification of whole brain cortices in patients with BD-I.
Methods : Twenty-two patients with BD-I and age and sex-matched 22 healthy controls (HC) were included in this study. All participants underwent T1-weighted structural magnetic resonance imaging (MRI). The local gyrification index (LGI) of 66 cortical regions were analyzed using the FreeSurfer (Athinoula A. Martinos Center for Biomedical Imaging). One-way analysis of covariance (ANCOVA) was used to analyze the difference of LGI values between two groups adjusting for age and sex as covariates.
Results : The patients with BD-I showed significant hypogyria in the left pars opercularis (uncorrected-p = 0.049), the left rostral anterior cingulate gyrus (uncorrected-p = 0.012), the left caudal anterior cingulate gyrus (uncorrected-p = 0.033). However, these findings were not significant after applying the multiple comparison correction. Severity or duration of illness were not significantly correlated with LGI in the patients with BD-I.
Conclusions : Our results of lower LGI in the anterior cingulate cortex and the ventrolateral prefrontal cortex in the BD-I group implicate that altered cortical gyrification in neural circuits involved in emotion-processing may contribute to pathophysiology of BD-I.
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KEYWORD
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Local gyrification index, Bipolar disorder, Ventrolateral prefrontal cortex, Anterior cingulate cortex, Emotion-processing neural circuit
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